Comparison between Del Nido and conventional blood cardioplegia in pediatric open-heart surgery.

ABSTRACT:

Background

Del Nido cardioplegia (DNc) was designed for superior myocardial protection during cardiopulmonary bypass (CPB). We conducted a retrospective review to explore if DNc was associated with increase in systemic ventricle dysfunction (sVD) following pediatric CPB.

Methods and results

This single-center, retrospective study included 1534 patients undergoing CPB between 2013 and 2016, 997 prior to center-wide conversion to DNc and 537 following. The primary outcome was new postoperative ≥moderate sVD by echocardiogram. Secondary outcomes included sVD of any severity and right ventricular dysfunction. Data was evaluated by interrupted time-series analysis. Groups had similar cardiac diagnoses and surgical complexity. Del Nido cardioplegia was associated with longer media

SUBMITTER: Floh AA 

PROVIDER: S-EPMC9932617 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature