Prescribed daily-dose-based metrics of oral antibiotic use for hospitalized children in Japan.

ABSTRACT:

Objective

Defined daily-dose (DDD)-based metrics are frequently used to measure antibiotic consumption. However, they are unsuitable for the pediatric population because they are defined using the maintenance dose for 70-kg adults. Moreover, children have large body weight variations. We assessed the prescribed daily dose (PDD) and PDD-based metrics of oral antibiotics for children to develop an alternative to DDD-based metrics in Japan.

Design

We performed observational study using data from the Japanese administrative claims database between April 2018 and March 2019.

Methods

Of 453,001 patients (aged 1 month-15 years), 564,326 admissions to 1,159 hospitals were included. We showed the median PDD (mg/day and mg/kg/day) and PDD-based metrics for 8 antibiotics for eac

SUBMITTER: Mimura W 

PROVIDER: S-EPMC9932642 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature