Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose.

ABSTRACT:

Background and purpose

Significant deviations between bladder dose planned (D_P) and dose accumulated (D_A) have been reported in patients receiving radiotherapy for prostate cancer. This study aimed to construct multivariate analysis (MVA) models to predict the risk of late genitourinary (GU) toxicity with clinical and D_P or D_A as dose-volume (DV) variables.

Materials and methods

Bladder D_A obtained from 150 patients were compared with D_P. MVA models were built from significant clinical and DV variables (p < 0.05) at univariate analysis. Previously developed dose-based-region-of-interest (DB-ROI) metrics using expanded ring structures from the prostate were included. Goodness-of-fit test and calibration plots w

SUBMITTER: Li Kuan Ong A 

PROVIDER: S-EPMC9932727 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature