Efficacy and safety of levetiracetam versus valproate in patients with established status epilepticus: A systematic review and meta-analysis.

ABSTRACT:

Objective

Status epilepticus (SE) is a common neurological emergency that is defined as a prolonged seizure or a series of seizures which often leads to irreversible damage. Levetiracetam (LEV) and valproate (VPA) are second-line anti-seizure drugs that are frequently used in patients with established SE (ESE). This meta-analysis compared the efficacy and safety of LEV and VPA for the treatment of ESE.

Method

MEDLINE, EMBASE, Central Register of Controlled Trials (CENTRAL), and clinicaltrials.gov were searched by two authors, which identified six randomized controlled trials (RCTs) that compared LEV and VPA for ESE.

Results

The six RCTs included 1213 patients (LEV group, n = 593; VPA group, n = 620). Integrated patient data information display LEV was not superior to

SUBMITTER: Wang S 

PROVIDER: S-EPMC9932733 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature