The Association of HLA Alleles and Haplotypes with Age of Disease Onset in Pakistani Psoriatic Patients.

ABSTRACT:

Introduction

The human leukocyte antigen (HLA) region on chromosome 6p21 is well known to carry the most important genetic factors in susceptibility to psoriasis. Different HLA alleles and haplotypes have been reported to be associated with psoriasis in different populations. Psoriasis has a variable age of onset and, based on this, it can be classified into two types; type I with age of onset before 40 years of age and type II with age of onset after 40 years of age. The objective of this study was to determine the association of HLA class I and class II alleles and haplotypes with disease and stratification using age of onset in Pakistani psoriatic patients.

Methods

A group of 603 individuals (326 cases and 277 controls) were analyzed for HLA class I and II alleles and hap

SUBMITTER: Munir S 

PROVIDER: S-EPMC9932843 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature