Ontology highlight
ABSTRACT:
SUBMITTER: Zhan Q
PROVIDER: S-EPMC9932901 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Zhan Qipeng Q Zhang Jianan J Lin Yubin Y Chen Wenjing W Fan Xinzou X Zhang Dunfang D
Frontiers in immunology 20230202
Sjogren's syndrome (SS) is a chronic autoimmune disease accompanied by multiple lesions. The main manifestations include dryness of the mouth and eyes, along with systemic complications (e.g., pulmonary disease, kidney injury, and lymphoma). In this review, we highlight that IFNs, Th17 cell-related cytokines (IL-17 and IL-23), and B cell-related cytokines (TNF and BAFF) are crucial for the pathogenesis of SS. We also summarize the advances in experimental treatment strategies, including targetin ...[more]