Low expression of HIF1AN accompanied by less immune infiltration is associated with poor prognosis in breast cancer.

ABSTRACT:

Background

Hypoxia-inducible factor 1-alpha (HIF-1α) stability and transcriptional action are reduced by the hypoxia-inducible factor 1-alpha subunit suppressor (HIF1AN). Its inappropriate expression is associated with the development of cancer and immune control. It is yet unknown how HIF1AN, clinical outcomes, and immune involvement in breast cancer (BC) are related.

Methods

Using the GEPIA, UALCAN, TIMER, Kaplan-Meier plotter, and TISIDB datasets, a thorough analysis of HIF1AN differential expression, medical prognosis, and the relationship between HIF1AN and tumor-infiltrating immune cells in BC was conducted. Quantitative real-time PCR (qRT-PCR) analysis of BC cells were used for external validation.

Results

The findings revealed that, as compared to standard spe

SUBMITTER: Tang S 

PROVIDER: S-EPMC9932925 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature