Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Antibiotics are an important risk for Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN), which are the most severe types of drug hypersensitivity reaction with a mortality rate up to 50%. To our knowledge, no global systematic review has described antibiotic-associated SJS/TEN.

Objective

To evaluate the prevalence of antibiotics associated with SJS/TEN worldwide.

Data sources

The MEDLINE and Embase databases were searched for experimental and observational studies that described SJS/TEN risks since database inception to February 22, 2022.

Study selection

Included studies adequately described SJS/TEN origins and specified the antibiotics associated with SJS/TEN.

Data extraction and synthesis

Two reviewers (E.Y.L. and C.K.) indep

SUBMITTER: Lee EY 

PROVIDER: S-EPMC9932945 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature