PM_2.5 induce lifespan reduction, insulin/IGF-1 signaling pathway disruption and lipid metabolism disorder in Caenorhabditis elegans.

ABSTRACT:

Introduction

Exposure to fine particulate matter (PM), especially PM_2.5, can induce various adverse health effects in populations, including diseases and premature death, but the mechanism of its toxicity is largely unknown.

Methods

Water-soluble components of PM_2.5 (WS-PM_2.5) were collected in the north of China in winter, and combined in two groups with the final concentrations of 94 μg/mL (C_L group, AQI ≤ 100) and 119 μg/mL (C_H group, 100 < AQI ≤ 200), respectively. The acute and long-term toxic effects of WS-PM_2.5 samples were evaluated in several aspects such as development, lifespan, healthspan (locomotion behavior, heat stress tolerance, lipofucin). DAF mutants and genes were applied to verify the actio

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9932997 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature