Tandem Protocol of Hexahydroquinoline Synthesis Using [H₂-DABCO][HSO₄]₂ Ionic Liquid as a Green Catalyst at Room Temperature.

ABSTRACT: Green, eco-benign, and sustainable synthesis is paramount in present chemistry. Here, a facile, efficient, and [H₂-DABCO][HSO₄]₂ ionic-liquid-catalyzed one-pot multicomponent synthesis of hexahydroquinolines was reported under ambient reaction conditions. The reaction of 1,3-dicarbonyls, malononitrile, and ammonium acetate with various aldehydes in the presence of an ionic liquid catalyst and EtOH solvent at room temperature afforded excellent yields (76-100%) of hexahydroquinolines under a short reaction time (5-15 min). Mild reaction conditions, broad substrate scope (28 derivatives), and column-chromatography-free synthesis with excellent catalytic efficiency and good recyclability rendered this protocol superior and practical. The greenness of the prese

SUBMITTER: Sahiba N 

PROVIDER: S-EPMC9933228 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature