Polymorphisms and gene expression of Notch4 in pulmonary tuberculosis.

ABSTRACT:

Background

Tuberculosis (TB) is a serious public health problem to human health, but the pathogenesis of TB remains elusive.

Methods

To identify novel candidate genes associated with TB susceptibility, we performed a population-based case control study to genotype 41SNPs spanning 21 genes in 435 pulmonary TB patients and 375 health donors from China.

Results

We found Notch4 gene rs206018 and rs422951 polymorphisms were associated with susceptibility to pulmonary tuberculosis. The association was validated in another independent cohort including 790 TB patients and 1,190 healthy controls. Moreover, we identified that the rs206018 C allele was associated with higher level of Notch4 in PBMCs from pulmonary TB patients. Furthermore, Notch4 expression increased in TB patie

SUBMITTER: Fang W 

PROVIDER: S-EPMC9933242 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature