Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men.

ABSTRACT:

Background

Age-related hearing loss (ARHL) is a common phenomenon observed during aging. On the other hand, the decrease in Nicotinamide adenine dinucleotide (NAD +) levels is reported to be closely related to the age-related declines in physiological functions such as ARHL in animal studies. Moreover, preclinical studies confirmed NAD + replenishment effectively prevents the onset of age-related diseases. However, there is a paucity of studies on the relationship between NAD⁺ metabolism and ARHL in humans.

Methods

This study was analyzed the baseline results of our previous clinical trial, in which nicotinamide mononucleotide or placebo was administered to 42 older men (Igarashi et al., NPJ Aging 8:5, 2022). The correlations between blood levels of NAD⁺

SUBMITTER: Nakagawa-Nagahama Y 

PROVIDER: S-EPMC9933288 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature