Causal relationships between migraine and microstructural white matter: a Mendelian randomization study.

ABSTRACT:

Background

Migraine is a disabling neurological disorder with the pathophysiology yet to be understood. The microstructural alteration in brain white matter (WM) has been suggested to be related to migraine in recent studies, but these evidence are observational essentially and cannot infer a causal relationship. The present study aims to reveal the causal relationship between migraine and microstructural WM using genetic data and Mendelian randomization (MR).

Methods

We collected the Genome-wide association study (GWAS) summary statistics of migraine (48,975 cases / 550,381 controls) and 360 WM imaging-derived phenotypes (IDPs) (31,356 samples) that were used to measure microstructural WM. Based on instrumental variables (IVs) selected from the GWAS summary statistics, we c

SUBMITTER: Zhao L 

PROVIDER: S-EPMC9933315 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature