Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure.

ABSTRACT: The barrier function of the skin is mainly assured by its outermost layer, stratum corneum (SC). One key aspect in predicting dermal drug delivery and in safety assessment of skin exposure to chemicals is the need to determine the amount of chemical that is taken up into the SC. We here present a strategy that allows for direct measures of the amount of various solid chemicals that can be dissolved in the SC in any environmental relative humidity (RH). A main advantage of the presented method is that it distinguishes between molecules that are dissolved within the SC and molecules that are not dissolved but might be present at, for example, the skin surface. In addition, the method allows for studies of uptake of hydrophobic chemicals without the need to use organic solvents. The strategy

SUBMITTER: Pham QD 

PROVIDER: S-EPMC9933541 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature