Interleukin 27 is a novel cytokine with anti-inflammatory effects against spondyloarthritis through the suppression of Th17 responses.

ABSTRACT:

Introduction

Spondylarthritis (SpA) development in HLA-B27/human β2-microglobulin transgenic rat (B27-rat) is correlated with altered conventional dendritic cell (cDC) function that promotes an inflammatory pattern of CD4+T cells, including a biased expansion of pro-inflammatory Th₁₇ population and imbalance of regulatory T cells cytokine profile. Transcriptomic analysis revealed that cDCs from B27-rats under express IL-27, an anti-inflammatory cytokine which induces the differentiation of IL-10⁺ regulatory T cells and inhibits Th₁₇ cells.

Methods

Here, we first investigated whether in vitro addition of exogenous IL-27 could reverse the inflammatory pattern observed in CD4⁺ T cells. Next, we performed preclinical assay using

SUBMITTER: Jouhault Q 

PROVIDER: S-EPMC9933703 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature