Blood-based biomarkers of antidepressant response to ketamine and esketamine: A systematic review and meta-analysis.

ABSTRACT: (R,S)-ketamine (ketamine) and its enantiomer (S)-ketamine (esketamine) can produce rapid and substantial antidepressant effects. However, individual response to ketamine/esketamine is variable, and there are no well-accepted methods to differentiate persons who are more likely to benefit. Numerous potential peripheral biomarkers have been reported, but their current utility is unclear. We conducted a systematic review/meta-analysis examining the association between baseline levels and longitudinal changes in blood-based biomarkers, and response to ketamine/esketamine. Of the 5611 citations identified, 56 manuscripts were included (N = 2801 participants), and 26 were compatible with meta-analytical calculations. Random-effect models were used, and effect sizes were reported as standardized

SUBMITTER: Medeiros GC 

PROVIDER: S-EPMC9933928 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature