Identification of risk genes in Chinese nonobstructive azoospermia patients based on whole-exome sequencing.

ABSTRACT: Nonobstructive azoospermia (NOA) is a severe condition in infertile men, and increasing numbers of causative genes have been identified during the last few decades. Although certain causative genes can explain the presence of NOA in some patients, a proportion of NOA patients remain to be addressed. This study aimed to investigate potential high-risk genes associated with spermatogenesis in idiopathic NOA patients by whole-exome sequencing. Whole-exome sequencing was performed in 46 male patients diagnosed with NOA. First, screening was performed for 119 genes known to be related to male infertility. Next, further screening was performed to determine potential high-risk causative genes for NOA by comparisons with 68 healthy male controls. Finally, risk genes with high/specific expression i

SUBMITTER: Liu YJ 

PROVIDER: S-EPMC9933954 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature