Patterns of circulating fat-soluble vitamins and carotenoids and risk of frailty in four European cohorts of older adults.

ABSTRACT:

Purpose

To investigate the cross-sectional and prospective associations between patterns of serum fat-soluble micronutrients and frailty in four European cohorts of older adults 65 years of age and older.

Methods

Participants from the Three-City (Bordeaux, France), AMI (Gironde, France), TSHA (Toledo, Spain) and InCHIANTI (Tuscany, Italy) cohorts with available data on serum α-carotene, β-carotene, lycopene, cryptoxanthin, lutein + zeaxanthin, retinol, α-tocopherol, γ-tocopherol and 25-hydroxyvitamin D3 (25(OH)D) were included. A principal component (PC) analysis was used to derive micronutrient patterns. Frailty was defined using Fried's criteria. Multivariate logistic regression models adjusted for socio-demographic and health-related covariates were performed to assess th

SUBMITTER: Pilleron S 

PROVIDER: S-EPMC9933998 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature