Social stress-induced serotonin dysfunction activates spexin in male Nile tilapia (Oreochromis Niloticus).

ABSTRACT: Social disturbance in interpersonal relationships is the primary source of stress in humans. Spexin (SPX, SPX1a in cichlid), an evolutionarily conserved neuropeptide with diverse physiological functions, is up-regulated in the brain during chronic social defeat stress in teleost. On the other hand, repeated exposure to social stress can lead to dysregulation of the monoaminergic system and increase the vulnerability of developing depression. Since dysfunction of the serotonin (5-hydroxytryptamine, 5-HT) system is associated with social stress and the pathophysiology of depression, the present study investigated the regulatory relationship between the central 5-HT system and SPX1a in the male teleost, Nile tilapia (Oreochromis niloticus). To identify stress factors that regulate SPX1

SUBMITTER: Lim CH 

PROVIDER: S-EPMC9934202 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature