Early peripheral blood MCEMP1 and HLA-DRA expression predicts COVID-19 prognosis.

ABSTRACT:

Background

Mass vaccination has dramatically reduced the incidence of severe COVID-19, with most cases now presenting as self-limiting upper respiratory tract infections. However, those with co-morbidities, the elderly and immunocompromised, as well as the unvaccinated, remain disproportionately vulnerable to severe COVID-19 and its sequelae. Furthermore, as the effectiveness of vaccination wanes with time, immune escape SARS-CoV-2 variants could emerge to cause severe COVID-19. Reliable prognostic biomarkers for severe disease could be used as early indicator of re-emergence of severe COVID-19 as well as for triaging of patients for antiviral therapy.

Methods

We performed a systematic review and re-analysis of 7 publicly available datasets, analysing a total of 140 severe a

SUBMITTER: Chan KR 

PROVIDER: S-EPMC9934388 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature