FHbp variants among meningococci of serogroup B in Italy: Evolution and selective pressure, 2014-2017.

ABSTRACT:

Background

Neisseria meningitidis (meningococcus) is the causative agent of invasive meningococcal disease (IMD). Meningococcus of serogroup B (MenB) is one of the main serogroup causing IMD. MenB strains may be prevented by meningococcal B vaccines. In particular, vaccines with Factor H-binding protein (FHbp), classified into two subfamilies (A or B) or in three variants (v1, v2 or v3), are those available. The objective of the study was to investigate the phylogenetic relationships of FHbp subfamilies A and B (variants v1, v2 or v3) genes and proteins, together with their evolution patterns and selective pressure.

Materials and methods

Overall, alignments of FHbp nucleotide and protein sequence from 155 MenB samples collected in different parts of Italy, from 2014 to 2017,

SUBMITTER: Lo Presti A 

PROVIDER: S-EPMC9934395 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature