HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex.

ABSTRACT: Accumulating evidence indicates that there are substantial species differences in the properties of mammalian neurons, yet theories on circuit activity and information processing in the human brain are based heavily on results obtained from rodents and other experimental animals. This knowledge gap may be particularly important for understanding the neocortex, the brain area responsible for the most complex neuronal operations and showing the greatest evolutionary divergence. Here, we examined differences in the electrophysiological properties of human and mouse fast-spiking GABAergic basket cells, among the most abundant inhibitory interneurons in cortex. Analyses of membrane potential responses to current input, pharmacologically isolated somatic leak currents, isolated soma outside-out

SUBMITTER: Szegedi V 

PROVIDER: S-EPMC9934405 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature