Bioabsorbable metal zinc differentially affects mitochondria in vascular endothelial and smooth muscle cells.

ABSTRACT: Zinc is an essential trace element having various structural, catalytic and regulatory interactions with an estimated 3000 proteins. Zinc has drawn recent attention for its use, both as pure metal and alloyed, in arterial stents due to its biodegradability, biocompatibility, and low corrosion rates. Previous studies have demonstrated that zinc metal implants prevent the development of neointimal hyperplasia, which is a common cause of restenosis following coronary intervention. This suppression appears to be smooth muscle cell-specific, as reendothelization of the neointima is not inhibited. To better understand the basis of zinc's differential effects on rat aortic smooth muscle (RASMC) versus endothelial (RAENDO) cells, we conducted a transcriptomic analysis of both cell types following

SUBMITTER: Bagshaw ORM 

PROVIDER: S-EPMC9934485 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature