Magnetic CuFe₂O₄ with intrinsic protease-like activity inhibited cancer cell proliferation and migration through mediating intracellular proteins.

ABSTRACT: Protease has been widely used in biological and industrial fields. Developing efficient artificial enzyme mimics remains a major technical challenge due to the high stability of peptide bonds. Nanoenzymes with high stability, high activity and low cost, provided new opportunities to break through natural enzyme inherent limitations. However, compared with many nanomaterials with inherent peroxidase activity, the intrinsic mimic proteases properties of magnetic nanomaterials were seldom explored, let alone the interaction between magnetic nanomaterials and cellular proteins. Herein, we reported for the first time that magnetic CuFe₂O₄ possesses inherent protease activity to hydrolyze bovine serum albumin (BSA) and casein under physiological conditions, and the CuFe

SUBMITTER: Chen D 

PROVIDER: S-EPMC9934488 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature