Vascular tissue engineering from human adipose tissue: fundamental phenotype of its resident microvascular endothelial cells and stromal/stem cells.

ABSTRACT: Adipose tissue is an abundant, accessible, and uniquely dispensable source of cells for vascular tissue engineering. Despite its intrinsic endothelial cells, considerable effort is directed at deriving endothelium from its resident stem and progenitor cells. Here, we investigate the composition of human adipose tissue and characterize the phenotypes of its constituent cells in order to help ascertain their potential utility for vascular tissue engineering. Unsupervised clustering based on cell-surface protein signatures failed to detect CD45^-CD31^-VEGFR2⁺ endothelial progenitor cells within adipose tissue, but supported further investigation of its resident CD45^-CD31⁺ microvascular endothelial cells (HAMVECs) and CD45^-CD31

SUBMITTER: Antonyshyn JA 

PROVIDER: S-EPMC9934493 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature