Dataset Information
The landscape of MHC-presented phosphopeptides yields actionable shared tumor antigens for cancer immunotherapy across multiple HLA alleles.
Ontology highlight
ABSTRACT:
SUBMITTER: Molvi Z
PROVIDER: S-EPMC9934604 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Publications
The landscape of MHC-presented phosphopeptides yields actionable shared tumor antigens for cancer immunotherapy across multiple HLA alleles.
bioRxiv : the preprint server for biology 20230212
<h4>Background</h4>Certain phosphorylated peptides are differentially presented by MHC molecules on cancer cells characterized by aberrant phosphorylation. Phosphopeptides presented in complex with the human leukocyte antigen HLA-A*02:01 provide a stability advantage over their nonphosphorylated counterparts. This stability is thought to contribute to enhanced immunogenicity. Whether tumor-associated phosphopeptides presented by other common alleles exhibit immunogenicity and structural characte ...[more]