Abnormal Intraepidermal Nerve Fiber Density in Disease: A Scoping Review.

ABSTRACT:

Background

Intraepidermal nerve fiber density (IENFD) has become an important biomarker for neuropathy diagnosis and research. The consequences of reduced IENFD can include sensory dysfunction, pain, and a significant decrease in quality of life. We examined the extent to which IENFD is being used as a tool in human and mouse models and compared the degree of fiber loss between diseases to gain a broader understanding of the existing data collected using this common technique.

Methods

We conducted a scoping review of publications that used IENFD as a biomarker in human and non-human research. PubMed was used to identify 1,004 initial articles that were then screened to select articles that met the criteria for inclusion. Criteria were chosen to standardize publications so th

SUBMITTER: Thomas SJ 

PROVIDER: S-EPMC9934806 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature