Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5.

ABSTRACT: Individuals over the age of 65 comprise a substantial portion of the world population and become more susceptible to vaccine-preventable infections with age as vaccination response diminishes. The underlying reason for this impaired vaccine response in older individuals is not entirely clear. We evaluated potential differences in phenotypic and functional responses of B cells from healthy younger (22-45years) and older (64-95years) individuals that may associate with a diminished antibody response to influenza vaccination. We report that age is associated with expansion of atypical memory B cells (CD10^-CD20⁺CD21^-CD27^-) and an age-associated B cell (ABC, CD21^-T-bet⁺CD11c⁺) phenotype. Reduced expression of PAX5 was

SUBMITTER: Nipper AJ 

PROVIDER: S-EPMC9934856 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature