Epstein-Barr virus dynamics and its prognostic impact on nasopharyngeal cancers in a non-endemic region.

ABSTRACT:

Background

Epstein-Barr virus (EBV) DNA quantification in nasopharyngeal cancer (NPC) is an indicator of the tumour burden, stage and survival. Although EBV dynamics in endemic regions has been extensively studied and reported, the data from non-endemic regions is sparse. This study attempts to investigate the EBV dynamics in NPC patients from a non-endemic region and also to identify the factors impacting the outcomes.

Materials and methods

This was a prospective observational study conducted at a tertiary care centre in South India and enrolled patients with non-metastatic, biopsy proven NPC, who were suitable for radical chemo-radiotherapy with or without induction chemotherapy. Two blood samples, one prior to initiation of any anticancer treatment, and second at 6 weeks

SUBMITTER: Ganapathi R 

PROVIDER: S-EPMC9934968 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature