Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle.

ABSTRACT:

Aims

Cardiac arrhythmia originating from the papillary muscle (PM) can trigger ventricular fibrillation (VF) and cause sudden cardiac death even in the absence of structural heart disease. Most premature ventricular contractions, however, are benign and hitherto difficult to distinguish from a potentially fatal arrhythmia. Altered repolarization characteristics are associated with electrical instability, but electrophysiological changes which precede degeneration into VF are still not fully understood.

Methods and results

Ventricular arrhythmia (VA) was induced by aconitine injection into PMs of healthy sheep. To investigate mechanisms of degeneration of stable VA into VF in structurally healthy hearts, endocardial high-density and epicardial mapping was performed during sin

SUBMITTER: Munkler P 

PROVIDER: S-EPMC9935011 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature