Atrial fibrillation onset before heart failure or vice versa: what is worst? A nationwide register study.

ABSTRACT:

Aims

Atrial fibrillation (AF) and heart failure (HF) often coexist. However, whether AF onset before HF or vice versa is associated with the worst outcome remains unclear. A consensus of large studies can guide future research and preventive strategies to better target high-risk patients.

Methods and results

We included all Danish cases with the coexistence of AF and HF (2005-17) using nationwide registries. Patients were divided into three separate groups (i) AF before HF, (ii) HF before AF, or (iii) AF and HF diagnosed concurrently (±30 days). Adjusting landmark Cox analyses (index date was the time of the latter diagnosis of AF or HF) were used for evaluating the association of the three groups with a composite outcome of ischaemic stroke or death. Among a total of 49 042

SUBMITTER: Pallisgaard J 

PROVIDER: S-EPMC9935045 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature