Directed self-assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes.

ABSTRACT: Intrahepatic islet transplantation is the standard cell therapy for β cell replacement. However, the shortage of organ donors and an unsatisfactory engraftment limit its application to a selected patients with type 1 diabetes. There is an urgent need to identify alternative strategies based on an unlimited source of insulin producing cells and innovative scaffolds to foster cell interaction and integration to orchestrate physiological endocrine function. We previously proposed the use of decellularized lung as a scaffold for β cell replacement with the final goal of engineering a vascularized endocrine organ. Here, we prototyped this technology with the integration of neonatal porcine islet and healthy subject-derived blood outgrowth endothelial cells to engineer a xenogeneic vascularized

SUBMITTER: Citro A 

PROVIDER: S-EPMC9935529 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature