No evidence for the benefit of PPIs in the treatment of acute pancreatitis: a systematic review and meta-analysis.

ABSTRACT: Although current guidelines do not recommend the use of proton pump inhibitors (PPIs) in the standard of care of acute pancreatitis (AP), they are often prescribed in clinical practice, mainly for ulcer stress prophylaxis. In this systematic review and meta-analysis we evaluated the association between the use of PPIs in the management of AP and various clinical outcomes. We conducted the systematic research in six databases without restrictions on January 24th, 2022. We investigated adult patient with AP, who were treated with PPI compared to conventional therapy. The pooled odds ratios, mean differences, and corresponding 95% confidence intervals were calculated with random effect model. We included six RCTs and three cohort studies, consisting of 28,834 patients. We found a significant

SUBMITTER: Horvath IL 

PROVIDER: S-EPMC9935541 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature