Antifungal alternation can be beneficial for durability but at the cost of generalist resistance.

ABSTRACT: The evolution of resistance to pesticides is a major burden in agriculture. Resistance management involves maximizing selection pressure heterogeneity, particularly by combining active ingredients with different modes of action. We tested the hypothesis that alternation may delay the build-up of resistance not only by spreading selection pressure over longer periods, but also by decreasing the rate of evolution of resistance to alternated fungicides, by applying an experimental evolution approach to the economically important crop pathogen Zymoseptoria tritici. Our results show that alternation is either neutral or slows the overall resistance evolution rate, relative to continuous fungicide use, but results in higher levels of generalism in evolved lines. We demonstrate that the nature of

SUBMITTER: Ballu A 

PROVIDER: S-EPMC9935548 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature