Left atrial strain correlates with severity of cardiac involvement in Anderson-Fabry disease.

ABSTRACT:

Objectives

Cardiac involvement in Anderson-Fabry disease (AFD) results in myocardial lipid depositions. An early diagnosis can maximize therapeutic benefit. Thus, this study aims to investigate the potential of cardiac MRI (CMR) based parameters of left atrial (LA) function and strain to detect early stages of AFD.

Methods

Patients (n = 58, age 40 (29-51) years, 31 female) with genetically proven AFD had undergone CMR including left ventricular (LV) volumetry, mass index (LVMi), T1, and late gadolinium enhancement, complemented by LA and LV strain measurements and atrial emptying fractions. Patients were stratified into three disease phases and compared to age and sex-matched healthy controls (HC, n = 58, age 41 [26-56] years, 31 female).

Results

A total of 19 early-,

SUBMITTER: Halfmann MC 

PROVIDER: S-EPMC9935647 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature