Delayed blastocyst development is influenced by the level of progesterone on the day of trigger.

ABSTRACT:

Purpose

To evaluate the association between progesterone (P) level on the day of trigger and time to blastulation in IVF cycles.

Methods

This was a retrospective cohort study with autologous IVF cycles performed at our Institution from January 2019 to December 2021. A total of 1109 IVF cycles were included. The primary outcome was to compare time to blastulation in terms of percentage of expanded (grade 3) blastocysts on day 5 according to progesterone level at trigger.

Results

A total of 3517 blastocysts were analyzed. After dividing progesterone level in quartiles (Q1, P < 0.50 ng/ml; Q2 0.50 ng/ml ≤ P ≤ 0.78 ng/ml; Q3, 0.79 ng/ml ≤ P ≤ 1.15 ng/ml; Q4, P > 1.15 ng/ml), we observed a delay in blastocyst development according to the increasing level of progesterone at

SUBMITTER: Villanacci R 

PROVIDER: S-EPMC9935760 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature