Correlation of peripheral blood and endometrial immunophenotyping in ART: is peripheral blood sampling useful?

ABSTRACT:

Purpose

Using a comprehensive flow cytometric panel, simultaneously obtained mid-luteal immunophenotypes from peripheral blood and endometrium were compared and values correlated. Is a peripheral blood evaluation of reproductive immunophenotype status meritorious relative to local endometrial evaluation to directly assess the peri-implantation environment?

Methods

Fifty-five patients had a mid-luteal biopsy to assess the local endometrial immunophenotype, while simultaneously providing a peripheral blood sample for analysis. Both samples were immediately assessed using a comprehensive multi-parameter panel, and lymphocyte subpopulations were described and compared.

Results

Distinct lymphocyte proportions and percentage differences were noted across the two compartment

SUBMITTER: Marron K 

PROVIDER: S-EPMC9935767 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature