CRISPR/Cas9 mediated gene editing in non-model nematode Panagrolaimus sp. PS1159.

ABSTRACT: The phylum Nematoda harbors a huge diversity of species in a broad range of ecosystems and habitats. Nematodes share a largely conserved Bauplan but major differences have been found in early developmental processes. The development of the nematode model organism Caenorhabditis elegans has been studied in great detail for decades. These efforts have provided the community with a large number of protocols and methods. Unfortunately, many of these tools are not easily applicable in non-Caenorhabditis nematodes. In recent years it has become clear that many crucial genes in the C. elegans developmental toolkit are absent in other nematode species. It is thus necessary to study the developmental program of other nematode species in detail to understand evolutionary conserv

SUBMITTER: Hellekes V 

PROVIDER: S-EPMC9935820 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature