Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial.

ABSTRACT: Many animal studies have shown that oral administration of the nicotinamide adenine dinucleotide (NAD⁺) precursor nicotinamide mononucleotide (NMN) prevents the reduction of NAD⁺ levels in organs and tissues, helping alleviate aging-related diseases. However, there are very few clinical reports of NMN supplementation in humans. Thus, this study aimed to investigate the influence of a 12-week NMN oral supplementation on biochemical and metabolic health parameters. A 12-week randomized, double-blind, placebo-controlled, parallel-group clinical trial was conducted. A total of 36 healthy middle-aged participants received one capsule of either 125 mg NMN or placebo twice a day. Among the NAD⁺ metabolites, the levels of nicotinamide in the serum were significantl

SUBMITTER: Katayoshi T 

PROVIDER: S-EPMC9935856 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature