Application of metagenomic next-generation sequencing in patients with infective endocarditis.

ABSTRACT:

Objectives

Metagenomic next-generation sequencing (mNGS) technology is helpful for the early diagnosis of infective endocarditis, especially culture-negative infective endocarditis, which may guide clinical treatment. The purpose of this study was to compare the presence of culture-negative infective endocarditis pathogens versus culture-positive ones, and whether mNGS test results could influence treatment regimens for patients with routine culture-negative infective endocarditis.

Methods

The present study enrolled patients diagnosed with infective endocarditis and tested for mNGS in the First Affiliated Hospital of Zhengzhou University from February 2019 to February 2022 continuously. According to the culture results, patients were divided into culture-negative group (Grou

SUBMITTER: Li SL 

PROVIDER: S-EPMC9936084 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature