A functional gene module identification algorithm in gene expression data based on genetic algorithm and gene ontology.

ABSTRACT: Since genes do not function individually, the gene module is considered an important tool for interpreting gene expression profiles. In order to consider both functional similarity and expression similarity in module identification, GMIGAGO, a functional Gene Module Identification algorithm based on Genetic Algorithm and Gene Ontology, was proposed in this work. GMIGAGO is an overlapping gene module identification algorithm, which mainly includes two stages: In the first stage (initial identification of gene modules), Improved Partitioning Around Medoids Based on Genetic Algorithm (PAM-GA) is used for the initial clustering on gene expression profiling, and traditional gene co-expression modules can be obtained. Only similarity of expression levels is considered at this stage. In the secon

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9936134 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature