The role of macrophages in fracture healing: a narrative review of the recent updates and therapeutic perspectives.

ABSTRACT:

Objective

This review addresses the latest advances in research on the role of macrophages in fracture healing, exploring their relationship with failures in bone consolidation and the perspectives for the development of advanced and innovative therapies to promote bone regeneration.

Background

The bone can fully restore its form and function after a fracture. However, the regenerative process of fracture healing is complex and is influenced by several factors, including macrophage activity. These cells have been found in the fracture site at all stages of bone regeneration, and their general depletion or the knockdown of receptors that mediate their differentiation, polarization, and/or function result in impaired fracture healing.

Methods

The literature search was c

SUBMITTER: Frade BB 

PROVIDER: S-EPMC9936163 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature