Sex-specific radiomic features of L-[S-methyl-¹¹C] methionine PET in patients with newly-diagnosed gliomas in relation to IDH1 predictability.

ABSTRACT:

Introduction

Amino-acid positron emission tomography (PET) is a validated metabolic imaging approach for the diagnostic work-up of gliomas. This study aimed to evaluate sex-specific radiomic characteristics of L-[S-methyl-¹¹Cmethionine (MET)-PET images of glioma patients in consideration of the prognostically relevant biomarker isocitrate dehydrogenase (IDH) mutation status.

Methods

MET-PET of 35 astrocytic gliomas (13 females, mean age 41 ± 13 yrs. and 22 males, mean age 46 ± 17 yrs.) and known IDH mutation status were included. All patients underwent radiomic analysis following imaging biomarker standardization initiative (IBSI)-conform guidelines both from standardized uptake value (SUV) and tumor-to-background ratio (TBR) PET values. Aligned Monte Carlo (MC) 1

SUBMITTER: Papp L 

PROVIDER: S-EPMC9936222 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature