Association of Dietary Nitrate and a Mediterranean Diet With Age-Related Macular Degeneration Among US Adults: The Age-Related Eye Disease Study (AREDS) and AREDS2.

ABSTRACT:

Importance

Low dietary nitrate intake has previously been suggested to be a risk factor for age-related macular degeneration (AMD) progression; however, this finding has not been replicated in other cohorts or adjusted for dietary patterns.

Objective

To determine whether there is an association between dietary nitrate intake and AMD progression.

Design, setting, and participants

This cohort study analyzed data from the prospective Age-Related Eye Disease Study (AREDS) and AREDS2 randomized clinical trial cohorts and their extended follow-up studies, which were conducted in multicenter outpatient retinal practices. Participants in both trials had non-late AMD in at least 1 eye. Data were analyzed from March 1, 2020, to September 30, 2022.

Exposure

Dietary nitrat

SUBMITTER: Broadhead GK 

PROVIDER: S-EPMC9936348 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature