Association of a Mediterranean Diet With Outcomes for Patients Treated With Immune Checkpoint Blockade for Advanced Melanoma.

ABSTRACT:

Importance

Immune checkpoint blockade (ICB) has improved the survival of patients with advanced melanoma. Durable responses are observed for 40% to 60% of patients, depending on treatment regimens. However, there is still large variability in the response to treatment with ICB, and patients experience a range of immune-related adverse events of differing severity. Nutrition, through its association with the immune system and gut microbiome, is a poorly explored but appealing target with potential to improve the efficacy and tolerability of ICB.

Objective

To investigate the association between habitual diet and response to treatment with ICB.

Design, setting, and participants

This multicenter cohort study (the PRIMM study) was conducted in cancer centers in the Netherl

SUBMITTER: Bolte LA 

PROVIDER: S-EPMC9936383 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature