Validation of genetic classifiers derived from mouse and human tumors to identify molecular subtypes of colorectal cancer.

ABSTRACT: Colorectal cancer (CRC) is a leading cause of cancer death in the United States. Standard treatment for advanced-stage CRC for decades has included 5-fluorouracil-based chemotherapy. More recently, targeted therapies for metastatic CRC are being used based on the individual cancer's molecular profile. In the past few years, several different molecular subtype schemes for human CRC have been developed. The molecular subtypes can be distinguished by gene expression signatures and have the potential to be used to guide treatment decisions. However, many subtyping classification methods were developed using mRNA expression levels of hundreds to thousands of genes, making them impractical for clinical use. In this study, we assessed whether an immunohistochemical approach could be used for mole

SUBMITTER: Snow SM 

PROVIDER: S-EPMC9936405 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature