Characterization of the skin microbiota in bullous pemphigoid patients and controls reveals novel microbial indicators of disease.

ABSTRACT:

Introduction

Bullous pemphigoid (BP) is the most common autoimmune blistering disease. It predominately afflicts the elderly and is significantly associated with increased mortality. The observation of age-dependent changes in the skin microbiota as well as its involvement in other inflammatory skin disorders suggests that skin microbiota may play a role in the emergence of BP blistering. We hypothesize that changes in microbial diversity associated with BP might occur before the emergence of disease lesions, and thus could represent an early indicator of blistering risk.

Objectives

The present study aims to investigate potential relationships between skin microbiota and BP and elaborate on important changes in microbial diversity associated with blistering in BP.

Methods

SUBMITTER: Belheouane M 

PROVIDER: S-EPMC9936408 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature