Soluble Trem2 is a negative regulator of erythrophagocytosis after intracerebral hemorrhage in a CD36 receptor recycling manner.

ABSTRACT:

Introduction

Microglia and macrophages participate in hematoma clearance after intracerebral hemorrhage (ICH), thereby facilitating tissue restoration and neurological recovery. Triggering receptor expressed on myeloid cells 2 (Trem2) has been indicated as a major pathology-induced immune signaling hub on the microglial/macrophage surface. Soluble Trem2 (sTrem2), the proteolytic form of Trem2, is abundant in the body fluid and is positively correlated with the pathological process.

Objectives

In the present study, we aimed to investigate the potential role of sTrem2 in hematoma resolution after ICH and to elucidate its underlying mechanisms.

Methods

We explored the biological functions of sTrem2 in the murine ICH brain by stereotaxic injection of recombinant sTrem2 pr

SUBMITTER: Zhou H 

PROVIDER: S-EPMC9936424 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature