Network-based modelling of mechano-inflammatory chondrocyte regulation in early osteoarthritis.

ABSTRACT: Osteoarthritis (OA) is a debilitating joint disease characterized by articular cartilage degradation, inflammation and pain. An extensive range of in vivo and in vitro studies evidences that mechanical loads induce changes in chondrocyte gene expression, through a process known as mechanotransduction. It involves cascades of complex molecular interactions that convert physical signals into cellular response(s) that favor either chondroprotection or cartilage destruction. Systematic representations of those interactions can positively inform early strategies for OA management, and dynamic modelling allows semi-quantitative representations of the steady states of complex biological system according to imposed initial conditions. Yet, mechanotransduction is rarely integrated. He

SUBMITTER: Segarra-Queralt M 

PROVIDER: S-EPMC9936426 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature