Identification and Analysis of Hub Genes and Immune Cells Associated with the Formation of Acute Aortic Dissection.

ABSTRACT:

Background

Acute type A aortic dissection (AAD) is a catastrophic disease with high mortality, but the pathogenesis has not been fully elucidated. This study is aimed at identifying hub genes and immune cells associated with the pathogenesis of AAD.

Methods

The datasets were downloaded from Gene Expression Omnibus (GEO). Gene Set Enrichment Analysis (GSEA), gene set variation analysis (GSVA), and differential analysis were performed. The differentially expressed genes (DEGs) were intersected with specific genes collected from MSigDB. The gene function and pathway enrichment analysis were also performed on intersecting genes. The key modules were selected by weighted gene coexpression network analysis (WGCNA). Hub genes were identified by least absolute shrinkage and selectio

SUBMITTER: Zhong A 

PROVIDER: S-EPMC9936456 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature